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URN: urn:nbn:de:kobv:517-opus-45260
URL: http://opus.kobv.de/ubp/volltexte/2010/4526/


Koseska, Aneta ; Zaikin, Alexey ; Kurths, Jürgen ; García-Ojalvo, Jordi

Timing cellular decision making under noise via cell-cell communication

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Kurzfassung auf Englisch

Many cellular processes require decision making mechanisms, which must act reliably even in the unavoidable presence of substantial amounts of noise. However, the multistable genetic switches that underlie most decision-making processes are dominated by fluctuations that can induce random jumps between alternative cellular states. Here we show, via theoretical modeling of a population of noise-driven bistable genetic switches, that reliable timing of decision-making processes can be accomplished for large enough population sizes, as long as cells are globally coupled by chemical means. In the light of these results, we conjecture that cell proliferation, in the presence of cell-cell communication, could provide a mechanism for reliable decision making in the presence of noise, by triggering cellular transitions only when the whole cell population reaches a certain size. In other words , the summation performed by the cell population would average out the noise and reduce its detrimental impact.

Institut: Institut für Physik und Astronomie
DDC-Sachgruppe: Physik
Dokumentart: c Postprint
Schriftenreihe: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, ISSN 1866-8372
Band Nummer: paper 148
Quelle: PLoS one 4 (2009), 3, Art. e4872, DOI: 10.1371/journal.pone.0004872
Sprache: Englisch
Erstellungsjahr: 2009
Publikationsdatum: 21.07.2010
Bemerkung:
The article was originally published by PUBLIC LIBRARY SCIENCE:
PLoS one. - 4 (2009), 3, Art. e4872 (6 S.)
ISSN 1932-6203
DOI 10.1371/journal.pone.0004872
Lizenz: Dieses Werk ist unter einer Creative Commons-Lizenz lizenziert.
Lizenz-Logo  Creative Commons - Attribution 3.0 unported


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