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URN: urn:nbn:de:kobv:517-opus-44947
URL: http://opus.kobv.de/ubp/volltexte/2010/4494/


May, Patrick ; Christian, Jan-Ole ; Kempa, Stefan ; Walther, Dirk

ChlamyCyc : an integrative systems biology database and web-portal for Chlamydomonas reinhardtii

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Kurzfassung auf Deutsch

Background:
The unicellular green alga Chlamydomonas reinhardtii is an important eukaryotic
model organism for the study of photosynthesis and plant growth. In the era of modern highthroughput technologies there is an imperative need to integrate large-scale data sets from highthroughput experimental techniques using computational methods and database resources to provide comprehensive information about the molecular and cellular organization of a single organism.

Results:
In the framework of the German Systems Biology initiative GoFORSYS, a pathway
database and web-portal for Chlamydomonas (ChlamyCyc) was established, which currently features about 250 metabolic pathways with associated genes, enzymes, and compound information. ChlamyCyc was assembled using an integrative approach combining the recently published genome sequence, bioinformatics methods, and experimental data from metabolomics and proteomics experiments. We analyzed and integrated a combination of primary and secondary database resources, such as existing genome annotations from JGI, EST collections, orthology information, and MapMan classification.

Conclusion:
ChlamyCyc provides a curated and integrated systems biology repository that will
enable and assist in systematic studies of fundamental cellular processes in Chlamydomonas. The ChlamyCyc database and web-portal is freely available under http://chlamycyc.mpimp-golm.mpg.de.

Freie Schlagwörter (englisch): Biochemical pathway database , Gene-expression data , Quantitative proteomics , Metabolic pathways , Genome annotation
Institut: Institut für Biochemie und Biologie
DDC-Sachgruppe: Biowissenschaften, Biologie
Dokumentart: c Postprint
Schriftenreihe: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, ISSN 1866-8372
Band Nummer: paper 127
Quelle: BMC Genomics 10 (2009), Art. 209, DOI: 10.1186/1471-2164-10-209
Sprache: Englisch
Erstellungsjahr: 2009
Publikationsdatum: 16.07.2010
Bemerkung:
The article was originally published by Biomed Central:
BMC Genomics. - 10 (2009), Art. 209 (8 S.)
ISSN 1471-2164
DOI 10.1186/1471-2164-10-209
Lizenz: Dieses Werk ist unter einer Creative Commons-Lizenz lizenziert.
Lizenz-Logo  Creative Commons - Namensnennung, 2.0 Deutschland


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