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URN: urn:nbn:de:kobv:517-opus-44570
URL: http://opus.kobv.de/ubp/volltexte/2010/4457/


Scholtka, Bettina ; Kühnel, Dana ; Taugner, Felicitas ; Steinberg, Pablo

Inflammation does not precede or accompany the induction of perneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats

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Kurzfassung auf Englisch

Heterocyclic aromatic amines (HCAs) are formed in meat cooked at high temperatures for a long time or over an open flame. In this context 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant HCA in cooked meat, has been suggested to be involved in colon and prostate carcinogenesis. In the latter case it has been reported that: (1) roughly 50% of Fischer F344 male rats treated with PhIP develop carcinomas in the ventral prostate lobe at 1 year of age; (2) inflammation precedes prostatic intraepithelial neoplasia in PhIP-fed rats; (3) inflammation specifically occurs in the ventral prostate lobe of PhIP-fed rats. To test whether PhIP by itself leads to inflammation in the colon and whether a human-relevant concentration of PhIP is able to induce preneoplastic lesions in the colon, male F344 rats were fed 0.1 or 100 ppm PhIP for up to 10 months and thereafter the colon tissue was analyzed histochemically. In none of the experimental groups signs of acute or chronic colonic inflammation were observed. 0.1 ppm PhIP leads to the development of hyperplastic and dysplastic lesions in the colon of single animals, but the incidence of these lesions does not reach a statistical significance. In contrast, in rats fed 100 ppm PhIP for 10 months hyperplastic and dysplastic colonic lesions were induced in a statistically significant number of animals. It is concluded that: (1) the induction of preneoplastic lesions in rat colon by PhIP is not preceded or accompanied by an inflammatory process; (2) a human-relevant concentration of PhIP alone is not sufficient to initiate colon carcinogenesis in rats.

Freie Schlagwörter (englisch): Colorectal cancer , Heterocyclic aromatic amines , Inflammation
Institut: Institut für Ernährungswissenschaft
DDC-Sachgruppe: Naturwissenschaften
Dokumentart: c Postprint
Schriftenreihe: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, ISSN 1866-8372
Band Nummer: paper 119
Quelle: Archives of Toxicology 83 (2009), 8, S. 763 - 768, DOI 10.1007/s00204-009-0406-2
Sprache: Englisch
Erstellungsjahr: 2009
Publikationsdatum: 06.07.2010
Bemerkung:
The original publication is available at:
www.springerlink.com
Archives of toxicology. - 83 (2009), 8, S. 763-768
ISSN 0340-5761
DOI 10.1007/s00204-009-0406-2
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