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URN: urn:nbn:de:kobv:517-opus-45846
URL: http://opus.kobv.de/ubp/volltexte/2010/4584/


Püschel, Gerhard ; Jungermann, Kurt

Activation of inositol phosphate formation by circulating noradrenaline but not by sympathetic nerve stimulation with a similar increase of glucose release in perfused rat liver

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Kurzfassung in Englisch

In the isolated rat liver perfused in situ, stimulation of the nerve bundles around the hepatic artery and portal vein caused an increase of glucose and lactate output and a reduction of perfusion flow. These changes could be inhibited completely by α-receptor blockers. The possible involvement of inositol phosphates in the intracellular signal transmission was studied.
1. In cell-suspension experiments, which were performed as a positive control, noradrenaline caused an increase in glucose output and, in the presence of 10 mM LiCl, a dose-dependent and time-dependent increase of inositol mono, bis and trisphosphate.
2. In the perfused rat liver 1 μM noradrenaline caused an increase of glucose and lactate output and in the presence of 10 mM LiCl a time-dependent increase of inositol mono, bis and trisphosphate that was comparable to that observed in cell suspensions.
3. In the perfused rat liver stimulation of the nerve bundles around the portal vein and hepatic artery caused a similar increase in glucose and lactate output to that produced by noradrenaline, but in the presence of 10 mM LiCl there was a smaller increase of inositol monophosphate and no increase of inositol bis and trisphosphate.
These findings are in line with the proposal that circulating noradrenaline reaches every hepatocyte, causing a clear overall increase of inositol phosphate formation and thus calcium release from the endoplasmic reticulum, while the hepatic nerves reach only a few cells causing there a small local change of inositol phosphate metabolism and thence a propagation of the signal via gap junctions.

Institut: Institut für Ernährungswissenschaft
DDC-Sachgruppe: Biowissenschaften, Biologie
Dokumentart: c Postprint
Schriftenreihe: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, ISSN 1866-8372
Bandnummer: paper 110
Quelle: European Journal of Biochemistry 175 (1988), 1, p. 187 - 191, DOI 10.1111/j.1432-1033.1988.tb14182.x , ISSN 0014-2956
Sprache: Englisch
Erstellungsjahr: 1988
Publikationsdatum: 04.08.2010
Bemerkung:
first published in:
FEBS Journal - 175 (1988), 1, p. 187-191
ISSN: 0014-2956
doi: 10.1111/j.1432-1033.1988.tb14182.x
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