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URN: urn:nbn:de:kobv:517-opus-45235
URL: http://opus.kobv.de/ubp/volltexte/2010/4523/

Mell, Thomas ; Wartenburger, Isabell ; Marschner, Alexander ; Villringer, Arno ; Reischies, Friedel M. ; Heekeren, Hauke R.

Altered function of ventral striatum during reward-based decision making in old age

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Kurzfassung in Deutsch

Normal aging is associated with a decline in different cognitive domains and local structural atrophy as well as decreases in dopamine concentration and receptor density. To date, it is largely unknown how these reductions in dopaminergic neurotransmission affect human brain regions responsible for reward-based decision making in older adults. Using a learning criterion in a probabilistic object reversal task, we found a learning stage by age interaction in the dorsolateral prefrontal cortex (dIPFC) during decision making. While young adults recruited the dlPFC in an early stage of learning reward associations, older adults recruited the dlPFC when reward associations had already been learned. Furthermore, we found a reduced change in ventral striatal BOLD signal in older as compared to younger adults in response to high probability rewards. Our data are in line with behavioral evidence that older adults show altered stimulus-reward learning and support the view of an altered fronto-striatal interaction during reward-based decision making in old age, which contributes to prolonged learning of reward associations.

Freie Schlagwörter (Englisch): aging , fMRI , reward association learning , ventral striatum , decision making , dorsolateral prefrontal cortex

Institut: Institut für Linguistik / Allgemeine Sprachwissenschaft

DDC-Sachgruppe: Sprachwissenschaft, Linguistik

Dokumentart: c Postprint

Schriftenreihe: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, ISSN 1866-8364

Bandnummer: paper 182

Quelle: Frontiers in human neuroscience 3 (2009), Art. 34, DOI: 10.3389/neuro.09.034.2009

Sprache: Englisch

Erstellungsjahr: 2009

Publikationsdatum: 21.07.2010

Bemerkung:
The article was originally published by Frontiers Media:
Frontiers in Human Neuroscience. - 4 (2009), Art. 34 (10 S.)
ISSN 1662-5161
DOI 10.3389/neuro.09.034.2009

Lizenz: Dieses Werk ist unter einer Creative Commons-Lizenz lizenziert.
Creative Commons - Attribution 3.0 unported

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