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URN: urn:nbn:de:kobv:517-opus-44353
URL: http://opus.kobv.de/ubp/volltexte/2010/4435/


Blenau, Wolfgang ; Rotte, Cathleen ; Witte, Jeannine ; Baumann, Otto ; Walz, Bernd

Source, topography and excitatory effects of GABAergic innervation in cockroach salivary glands

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Kurzfassung in Englisch

Cockroach salivary glands are innervated by dopaminergic and serotonergic neurons. Both transmitters elicit saliva secretion. We studied the distribution pattern of neurons containing gamma-aminobutyric acid ( GABA) and their physiological role. Immunofluorescence revealed a GABA-immunoreactive axon that originates within the subesophageal ganglion at the salivary neuron 2 (SN2) and this extends within the salivary duct nerve towards the salivary gland. GABA-positive fibers form a network on most acinar lobules and a dense plexus in the interior of a minor fraction of acinar lobules. Co-staining with anti-synapsin revealed that some putative GABAergic terminals seem to make pre-synaptic contacts with GABA-negative release sites. Many putative GABAergic release sites are at some distance from other synapses and at distance from the acinar tissue. Intracellular recordings from isolated salivary glands have revealed that GABA does not affect the basolateral membrane potential of the acinar cells directly. When applied during salivary duct nerve stimulation, GABA enhances the electrical response of the acinar cells and increases the rates of fluid and protein secretion. The effect on electrical cell responses is mimicked by the GABA(B) receptor agonists baclofen and SKF97541, and blocked by the GABAB receptor antagonists CGP52432 and CGP54626. These findings indicate that GABA has a modulatory role in the control of salivation, acting presynaptically on serotonergic and/or dopaminergic neurotransmission.

Freie Schlagwörter (Englisch): GABA , salivary gland , innervation , cockroach , Periplaneta americana
Institut: Institut für Biochemie und Biologie
DDC-Sachgruppe: Biowissenschaften, Biologie
Dokumentart: c Postprint
Schriftenreihe: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, ISSN 1866-8372
Bandnummer: paper 111
Quelle: Journal of experimental biology 212 (2009), 1, S. 126 - 136, DOI 10.1242/jeb.020412
Sprache: Englisch
Erstellungsjahr: 2009
Publikationsdatum: 02.07.2010
Bemerkung:
The article was originally published by The Company of Biologists:
Journal of experimental biology. - 212 (2009), 1, S. 126-136
ISSN 0022-0949
DOI 10.1242/jeb.020412
Lizenz: Diese Nutzungsbedingung gilt nicht, wenn in den Metadaten eine modifizierende Lizenz genannt ist. Keine Nutzungslizenz vergeben - es gilt das deutsche Urheberrecht


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